Men’s Hormone Optimization

1. Testosterone 

Primary androgen responsible for muscle mass, libido, motivation, and energy. Declines about 1% per year after age 30–35. Therapeutic forms include injectable cypionate/enanthate, transdermal gels, and oral testosterone undecanoate. Monitoring involves CBC, PSA, estradiol, lipids, and total/free testosterone levels. 

2. DHEA (Dehydroepiandrosterone) 

Adrenal precursor to androgens supporting energy, mood, and immunity. Typical doses 25–50 mg/day. Overuse may cause acne or hair loss.  

3. Thyroid Hormones 

Regulate metabolism, energy, and cognitive performance. Only treat confirmed hypothyroidism with levothyroxine (T4) or combination T4/T3. Monitor TSH, free T4, free T3 every 3–6 months. 

4. Growth Hormone (GH) and IGF-1 Axis 

Supports muscle, fat metabolism, and tissue repair. FDA-approved GH therapy is only for confirmed GH deficiency. Tesamorelin and related peptides may support GH pathways when clinically indicated.  

5. Cortisol and Stress Hormones 

Chronic cortisol elevation suppresses testosterone and accelerates aging. Optimization includes stress reduction, sleep hygiene, adaptogens, and peptides such as Thymosin α-1.   

FDA-Approved Peptides for Men’s Health 

Peptide	FDA-Approved Use	Function	Common Dose	Cautions
Tesamorelin (Egrifta SV)	HIV-associated lipodystrophy	Stimulates GH release, reduces visceral fat	2 mg SC daily	May increase glucose
Bremelanotide (Vyleesi)	HSDD (female); research for male libido	Melanocortin agonist, enhances libido	1.75 mg SC as needed	Flushing, transient BP rise
Liraglutide / Semaglutide / Tirzepatide	Diabetes, obesity	GLP-1/GIP agonist for fat loss and insulin sensitivity	Weekly SC injection	GI upset, nausea

These compounds are not FDA-approved for human use unless otherwise stated. Their application must comply with compounding regulations.  

Peptide	Mechanism	Potential Benefit	Evidence Status
CJC-1295 / Ipamorelin	GH secretagogues	Increase muscle, reduce fat	Early clinical data
BPC-157	Tissue repair peptide	Gut and joint healing	Animal studies only
Thymosin α-1	Immune modulation	Enhance immune response	Limited U.S. access
GHK-Cu	Copper-binding peptide	Skin regeneration	Cosmetic topical use
MOTS-c	Mitochondrial peptide	Metabolic health and endurance	Preclinical data

Comprehensive Anti-Aging Approach at MCNYC 

1. Assessment — medical history, labs, hormone and metabolic panels.  
2. Treatment — individualized testosterone therapy, peptide support, and metabolic optimization. 
3. Monitoring — ongoing lab review and adjustment for safety and efficacy.